Sentence examples for vitro models when from inspiring English sources

For example, the use of comparatively simple in vitro models when screening for novel antimicrobial drug candidates and investigating putative virulence factors in microbial pathogens is well established.

This study therefore found some differences between in vitro and animal models when compared to this in vivo assessment and supports the hypothesis that the course of an MRSA infection can be altered in recognition of host-specific signals.

The M2 cell culture showed a statistically significant higher capability to cross the in vitro BBB model when compared to M1).

In these studies, over-expression of CEACAM1-4L lead to significantly lower growth rates and less tumorigenicity in both in vitro and in vivo models when compared with un-transfected tumor cells [32] [36].

Among the numerous compounds tested as putative modulators, 2′-deoxyinosine (d-Ino) is a non-toxic precursor of the TP cofactor, deoxyribose 1-phosphate, that has been shown to enhance 5-FU's antiproliferative activity in several in vitro and in vivo models, when either used alone or combined with gene therapy strategies targeting TP (Ciccolini et al, 2000a, 2000b; Fanciullino et al, 2006).

When in vitro models are available that either have a high human predictive value or are physiologically similar to the human situation, experimental data can be used to develop in silico models that will eventually be able to predict the human in vivo bioavailability of nanoparticles from their in vitro translocation rate.

When all in vitro models displayed a significant difference in gene expression from the tumour specimen, we determined, when possible, the model which was closest to the in vivo situation.

However, caution must be extended when comparing in vitro models to the multi-factorial and multi-cellular in vivo environment.

Neurons and glia are intimately related throughout the nervous system, and the level of complexity surrounding their responses to each other means that, when considering in vitro models, it is often more appropriate to use cocultures of neurons and glia rather than try to study either cell type in isolation.

Neither [11C]A-740003 nor [11C]SMW64-D16 showed appreciable brain uptake; however, both succeeded in recognising the site of inflammation in two different rodent models when examined by in vitro autoradiography [5, 6].

ES cells also exhibit the capacity to contribute to a wide range of well-defined cell types when using several in vitro models of differentiation.