Sentence examples for vitro models such from inspiring English sources
Factors increasing the complexity of the assay systems are included in the following section describing the incorporation of components of natural systems to the in vitro models, such as in soil and water microcosm experiments.
Efforts to improve in vitro models such that they more closely mimic the in vivo conditions, such as exposure mechanism and dose, and potential for transport of NMs across cells are being developed rapidly, driven partially by the strong push within the EU to reduce animal testing.
This allows for communication between different cell types implemented in degenerative joint diseases that cannot be mimicked in other in vitro models, such as cartilage explants.
More complex in vitro models, such as brain slices, have also been adapted to study functional correlates of complex behaviors, such as long-term potentiation and synaptic plasticity.
It is conceivable that this may explain apparent discrepancies in effects obtained by different in vitro models, such as the reported biodiesel effects discussed above.
Although in vivo studies elucidating the molecular mechanisms taking place during adipogenesis are still limited, cellular in vitro models, such as the 3T3-L1 preadipocell celineine have been instrumental to study this process.
In the present scenario, only few in vitro ischemia models such as cerebral ischemia model based on organotypic hippocampal slice cultures and tissue culture ischemia model of oxygen/glucose deprivation are documented [3], [4].
OGD, in contrast to other in vitro ischemic models such as glutamate excitotoxicity, might be more suitable to mimic this in vivo situation, as it allows for more than one pathomechanism elicited by energy depletion to occur.
These tests are usually based on the ECG: QTc interval prolongation from in vitro animal models (such as wedge preparations and Langendorff-perfused heart), in vivo animal models, clinical trials, and eventually human thorough QT trials, specified by the ICH E14 document.
4) The authors generate valuable H3K9me2 and H3K27me3 ChIP-seq datasets from epiblast cells of E6.25 embryos, but I feel they missed the opportunity to provide a deeper comparison of their results with the H3K9me2 and H3K27me3 patterns reported from the in vitro cellular models such as EpiLC or EpiSC.
The antioxidant activity of the extracts were characterized in various in vitro model systems such as FTC, TBA, DPPH radical, reducing power and NO radical.
