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Among them, in vitro models represent suitable alternatives to in vivo models for numerous technical, practical, and ethical reasons.
Such biomimetic 3-D in vitro models represent a distinct advance on the traditional 2-D constructs [16].
Many efforts have been taken in order to shed light on the physiological, pathological, and toxicological aspects of human pregnancy, and in vitro models represent a valid help for researchers in this field.
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In vitro models representing the essential absorption barriers of the body are nowadays available, thus allowing investigation of the parameters that control permeability as well as transport processes across those barriers.
The model reported herein is to our knowledge the first in vitro model representing tridimensionally the situation which occurs in vivo between a neurogenic region (SVZ) and a target region after a brain insult.
We have characterised the epigenetic landscape of the in vivo primed pluripotent cells relative to its in vitro model represented by EpiSCs.
The chosen in vitro model represents different stages of osteoblastic development and has been valuable in analysing the patterns of expression of the genes of interest in different levels of osteoblastic maturity.
Cellular in vitro models may represent interesting tools to predict the potential toxic effects of drugs and treatments to be tested.
Ex vivo models represent a promising alternative to simple in vitro systems or complex, ethically challenging in vivo models.
In the current work, we studied the mechanisms regulating SOD3 expression in vitro using thyroid cell models representing different stages of thyroid cancer.
Using an in vitro model system representing various stages of breast oncogenesis, LEA.92 was detected on normal or immortalised mammary epithelial cell (MEC) lines which were dependent on epidermal growth factor (EGF) and anchorage formation for growth and non-tumorigenic in nude mice.
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