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Such approach, alongside in vitro models, is effective for screening purposes [1].
The information from both in situ and in vitro models is being used to refine noncell-based permeability assays.
However, the predictive value of animal and in vitro models is sometimes misleading and may have led to failures of translation into the clinical practice for many years [20].
The innovative use of in vitro models is also encouraged.
One aspect that has been scarcely explored with in vitro models is the immunological component of the disease.
Studying cell cell communication is difficult in tissue, so the availability of complementary in vitro models is helpful.
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"In vitro models are cleaner".
In vitro models are needed to study the pathophysiology of human IAS disorders.
For studying cellular processes three-dimensional (3D) in vitro models are of a high importance.
Reliable in vitro models are required to understand the ability of cells to respond and adapt to mechanical stimuli.
Although prokaryotic and eukaryotic cell models developed in our laboratory and others have advanced our understanding of many aspects of genotoxicity, in vitro models are needed to assess the risk to humans from space radiation insults.
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