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Many research efforts seek new innovative approaches to in vitro modelling of in vivo complexity without clear progress or improved relevance.
To assess the efficacy of GLOBE to correct HbA deficiency, transduced and control cells (n = 10) were grown in erythroid unilineage culture, as in vitro modelling of erythropoiesis.
Association of CXCR4 and CXCR7 with recurrence in oestrogen receptor positive breast cancer treated with endocrine therapy and in vitro modelling of short (STED) or late oestrogen deprivation (LTED).
These systems in turn permit in vitro modelling of human neuronal injury and, along with recent reports of astrocyte generation from HESCs, further allow study of glial neuronal interaction [ 54, 65].
Human cancers have been found to generate a reactive stroma, which can promote tumorigenesis and influence epithelial cell invasion during in vitro modelling of prostate cancer invasion (Lang et al, 2000).
The analysis of these problems has been limited by lack of reagents, as well as cellular and molecular tools for in vitro modelling of senescent-immune cell interactions as well as gain or loss-of-function approaches to evaluate induction and clearance of endogenous senescent cells.
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In vitro model of hypoxically induced nonreplicating persistence of Mycobacterium tuberculosis.
Dembele, L. et al. Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery.
Kahn, J. et al. Gene expression profiling in an in vitro model of angiogenesis.
An in vitro model of bacterial infections in wounds and other soft tissues.
To accomplish this, we used Id3 specific siRNA in an in vitro model of corneal fibrosis.
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