Sentence examples for vitro model where from inspiring English sources

Nanoparticle in cancer treatment was studied using an in vitro model, where uptake of the polylactic-co-glycolic acid (PLGA) nanoparticles coated with polyvinyl alcohol (PVA) was shown to be 1.4 times less than that coated with vitamin E TPGS on a colorectal cancer cell line [45].

Furthermore, others have reported vessel occlusion following Dll4-inhibition in an in vitro model, where HUVEC sprouting in fibrin gels led to the loss of lumen-like structures, which were replaced by densely packed endothelial cells [21].

The divergence could come from their in vitro model where combined osteoblasts and osteoclasts are grown in a well-regulated environment whereas in the in vivo model the number of variables involved in the osteoblast-osteoclast interaction is substantial.

To determine whether the activation of Jnk was physiologically relevant in hematopoietic progenitor cells, we first wanted to establish an in vitro model where the effect of Wnt4 on LMPPs could be reproduced.

In this study, we examined the effects of retinal microglia on RPE cells using 1) an in vitro model where activated retinal microglia are co-cultured with primary RPE cells, and 2) an in vivo mouse model where retinal microglia are transplanted into the subretinal space.

One approach to identify direct developmental neurotoxicity is to use an in vitro model, where these confounding factors do not operate.

This contrasts with the traditional in vitro models where extraembryonic endoderm cells are generated in abnormal ways, i.e. from ES cells [43] (likely through a re-commitment - see discussions in references [16], [44]) or embryonic carcinoma cells [45].

Still, insulin may react differently in in vitro models where one explanation is different stability or activity of insulin.

Further evidence stemmed from murine in vivo and in vitro models, where the uptake of recombinant α-Synuclein fibrils in neurons was detected, followed by the induction of α-Synuclein aggregation [ 12, 16, 44, 45, 49, 50, 74].

Conversely, Arb inhibition of HCVpp membrane fusion, as assessed by a in vitro model system where the only proteins present are the viral glycoproteins, could merely reflect the interaction of Arb on lipids and/or on motifs present in HCV glycoproteins of any genotype.

To the authors' knowledge, this is the first time GNP-mediated chemoradiation was tested in an in vitro cell model, where the cells were incubated with a nanomolar concentration of GNPs, and where a 6 MV radiation was used.