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That MR imaging can reliably and directly allow assessment of spinal ligament disruption in this in vitro model suggests its potential utility for this assessment in patients.
Additionally, the lack of changes in mitochondrial morphology (i.e. cristae) during acute exposure to Tat in our in vitro model, suggests that this phenomenon is dependent on pathways that subserve an inflammatory response only present in an in vivo milieu.
The in vitro model suggests that gefitinib may have differential effects in response to concomitant cytotoxic chemotherapy with the agents tested during this study.
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Previous in vitro model suggest this refers to an inherent property of spinal motoneurons themselves [ 21].
Preliminary results from our in vitro model suggest that the sequence 24 h MTA → 1 h dFdC → RT is the most rational design.
Of interest, the overexpression of C-II Ip or Fp subunits has been found to be neuroprotective against mHtt toxicity in this in vitro model, suggesting a key role of C-II in HD pathogenesis.
Therefore, the data from our in vitro model suggest that for patient-used endoscopes the chance of organisms surviving device reprocessing and being transmitted to another patient would be greater if BBF has developed within the endoscope channels.
Furthermore, cadherin-11 facilitated synoviocyte invasion into cartilage-like extracellular matrix in an in vitro model, suggesting that this molecule could serve as a specific target for therapy against cartilage destruction in inflammatory arthritis [ 178].
Results from our in vitro model suggest that the sequence 24 h MTA → 1 h dFdC → RT is the most rational design and would, after confirmation in an in vivo setting, possibly provide the greatest benefit in the clinic.
Estimates of a high sieving coefficient and short circuit half-life from this in vitro model suggest ceftriaxone is rapidly cleared during CVVH (almost entirely cleared by 240 min).
Thus, we evaluated whether AZD1152 could enhance the efficacy of gemcitabine in a pancreatic cancer in vitro model, suggesting the molecular pathways that are activated and required for treatments efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com