Sentence examples for vitro model relevant from inspiring English sources

To further examine the role of autophagy in bone loss in an in vitro model relevant for the human condition of critical illness, PBMCs were isolated, and pooled from an age-, sex-, and BMI-matched set of critically ill patients and healthy controls, and analysed for osteoclast formation in the presence of the autophagy inducer rapamycin.

We therefore characterized the phosphoprotein signaling by RVFV in the human small airway lung epithelial cells (HSAECs) as an in vitro model relevant to aerosol exposure.

Thus, the identification of an in vitro model system relevant to patient survival provides an invaluable tool, not only to further our understanding of how these cells self-renew and form tumours, but also to develop effective therapeutics.

Because increased GC resistance is one of the hallmarks of relapse in ALL, this provides encouraging evidence that the GC-resistance signature derived from this in vitro model is relevant to the in vivo situation.

Moreover, in vitro models are relevant not only to tissue engineering and regenerative medicine but also as platforms for high throughput screening of therapeutic drugs.

However, the extent to which and the mechanisms by which 27-OHC may also cause Aβ accumulation and cell death in in vitro model that is relevant to retinal pigment epithelial cells and AMD studies are lacking.

This review describes the state-of-the-art on in vitro BBB models relevant in drug discovery research and highlights their strengths, weaknesses and the utility potential of some of these models in testing the permeability of nanocarriers as vectors for delivering therapeutics to the brain.

The objective of this work was to develop an in vitro model in a clinically relevant system.

Evaluating whether brain tissue-specific (or non-specific) ECM coating improves neuronal network formation and function will be important for developing an in vitro model that is more relevant to the in vivo brain and can be used for evaluating potential neurotoxins and novel therapeutics.

Therefore, our study shows the utility of the PCgel as a depot for release of T lymphocytes and a convenient and valuable in vitro model for studying clinically relevant improvements to glioblastoma immunotherapy.

However, these preclinical studies have had limited impact in the management of breast cancer patients [ 17, 18], partly due to the incomplete understanding of the similarities and differences between these in vitro model systems and their relevant in vivo tumor counterparts.