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Two neuroblastoma cell lines, chemotherapeutic sensitive Kelly and chemotherapeutic resistant KellyCis83 were cultured in a 3D in vitro model on two collagen-based scaffolds containing either glycosaminoglycan (Coll-GAG) or nanohydroxyapatite (Coll-nHA) and compared to 2D cell culture and an orthotopic murine model.
In a first step, our findings demonstrated solid data of evidence for an impact of an in vitro model on gene expression.
In vitro model on CRC cell lines had suggested that the activity of SN-38 is synergic to L-OHP plus 5-FU-FA when delivered 24 48 h before.
In addition to the influence of the in vitro model on gene expression, there was a significant tumour effect (F-Ratio=42; Degree Freedom=2; P<0.001) and a significant gene effect (F-ratio=171; Degree Freedom=27; P<0.001).
The objective of this study was to assess the genotoxic effect exerted by fine particles collected in seven tunnels using the cytokinesis-block micronuclei test in an in vitro model on type II lung epithelium A549 cells.
Even though our study was conducted using in vitro model on NIH 3T3 fibroblast cell, Heng's [ 38] study had supported our findings and they claimed that sugar dressings (maltodextrin) tested on wounded dogs and cats in a veterinary clinical study capably drew macrophages into the wound and accelerated sloughing of necrotic tissue which enhanced the recovery rate of wound healing process.
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Additionally, Lee et al tested GFW in the in vitro model of IBD on HT-29 cells.
Herein, the present research was aimed to assess melatonin action on tumour angiogenesis in an in vitro model of HCC, focusing on its ability to interfere with the transcriptional activation of VEGF via Hif1 and STAT3.
This study was designed to evaluate the potential protective role of α7 nicotinic receptor activation in an in vitro model of neurodegeneration based on subchronic oxidative stress.
We here utilized an in vitro model of serum adsorption based on that described by Cantaluppi et al. to remove resistin from serum samples with elevated levels of this cytokine [28].
In an in vitro model of endothelial cell differentiation on a three-dimensional collagen gel, HB-19 and anti-nucleolin mAb inhibited formation of capillary-like branched structures induced by angiogenic growth factors PTN and VEGF (Figure 6C).
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