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We were somewhat surprised to find that the preliminary data obtained with this in vitro model, in which mucosa lacks blood perfusion, are consistent with those obtained from specimens of in-vivo induced esophagin-vivo induced
The objective of this work was to develop an in vitro model in a clinically relevant system.
Human hepatocytes cultured in a monolayer configuration represent a well-established in vitro model in liver toxicology, notably used in drug transporter studies.
To reproduce the earliest phases of endometriosis using a new in vitro model in which cells from a cultured endometrial fragment can proliferate, invade, reconstitute new endometrial-like tissue, and generate blood vessels.
Toward establishing such an in vitro model, in the current study, porcine aortic and pulmonary valvular interstitial cells (i.e. biomimetic cells) were cultivated on anisotropic, micromolded poly(glycerol sebacate) scaffolds (i.e. biomimetic scaffolds).
To assess whether BMPs would influence the three-dimensional architecture of epithelial structures, we took advantage of an in vitro model in which mammary epithelial cells form alveolar-like spherical cysts in collagen gels.
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Mattei, G., Giusti, S. & Ahluwalia, A. Design criteria for generating physiological relevant in vitro models in bioreactors.
Our results show that it is crucial to develop defined in vitro models in order to predict whether siderophores are social, cheatable and suitable for clinical exploitation in specific infection contexts.
Thereby, HDD can complement established tools and in vitro models in important applications including drug screening and biomaterial development.
Cell lines are widely used in many aspects of laboratory research and particularly as in vitro models in cancer research.
The workflow is applicable to all 'black-box' models, including high-throughput in vitro models in which output measures are affected by a set of experimental perturbations.
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