Sentence examples for vitro model has from inspiring English sources
This study was designed to examine the conversion of l-kynurenine to kynurenic acid and to investigate the effects of kynurenic acid on pentylenetetrazole-treated rat brain slices, and in parallel to draw attention to the fact that a well-designed in vitro model has many advantages in pharmacological screening.
As shown in Figure 3B E, the signature derived from the in vitro model has an ability to accurately predict the status of human primary breast cancer samples from three independent datasets, validating the predictive ability of the signature.
An oncogenic role for JCV has been demonstrated in several animal studies including rodents and primates (reviewed in [30]), but the lack of an adequate in vitro model has hampered our understanding of the role of JCV in human cancer.
This in vitro model has limitations in that cells are derived from naïve mice rather than from tumor-bearing mice.
A new in vitro model has been developed for investigating extravascular diffusion of therapeutic agents in tumour tissue.
Interestingly, a similar observation about a peak effect of 50% xenon in the same in vitro model has been made by Coburn and colleagues.
The determination of glutathione content and the parallel plate flow chamber in vitro model have been described in detail previously (8, 18, 19).
Adding physiological concentrations of calcitriol 10-100 mol/l) to this in vitro model had a beneficial effect on the endothelial expression of pro-inflammatory parameters, probably through the NFκB signal transduction pathway [ 16].
Sepsis has been shown to precondition the intact heart against ischaemia/reperfusion (IR) injury, and prior endotoxin exposure of cells in in vitro models has shown evidence of protection against subsequent simulated ischaemia.
However, EMT phenotyping in these in vitro models has not been systematically explored.
The use of in vitro models has been shown to provide an acceptable assessment of delivery in vivo [ 33, 71].
