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Our results indicate that the activity of 1D09C3 in vitro may have been a consequence of assay design rather than an ability to induce HLA-DR-dependent cell death.
The ability to culture these cells in vitro may have wide ranging applications in the clinic including augmenting repair of broken bones and treatment of osteoporosis.
The switching of cagPAI-dependent to cagPAI-independent signalling by induction of TLR-2 and TLR-5 in vitro may have important implications on H. pylori-associated pathologies in vivo.
The lack of cumulus cells and stress of the conditions in vitro may have influenced turnover of amino acids, and owing to the small sample sizes further studies are required to confirm these findings.
This provides the requisite experimental evidence that some cells in vitro may have acquire the attributes of the bipotent NMPs, which are presumed to exist in the node-streak interface and the chordoneural hinges in vivo.
The new pathway of TTR amyloidogenesis, which we have now characterized in vitro, may have important implications for drug development, including the tetramer stabilizing drugs currently in clinical trials.
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Antibodies that show anti-C2 activity in-vitro may have the ability to inhibit the deleterious effects of circulating congopain in-vivo such as immunosuppression, which may aid in reducing the pathological effects of trypanosomosis [ 12].
The ethical objections to in vitro fertilization may have been one reason for the long delay.
However, it is important to acknowledge that all in vitro models may have advantages and disadvantages72, and further studies using other models are needed to support the current results.
Our findings support the hypothesis that anti-apoptotic gene-modified MSCs can differentiate into cells with a nucleus pulposus-like phenotype in vitro, which may have value for the regeneration of intervertebral discs using cell transplantation therapy.
This finding represents the first unambiguous demonstration of resuscitation of dormant tubercle bacilli in vitro and may have implication for the study of mycobacterial dormancy and the design of novel strategies for improved treatment of tuberculosis.
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