Recombinant His(6 -SOBER1 hydrolyzed PC but not PA or LysoPC in vitro indicating that the enzyme has phospholipase A(2) (PLA(2)) activity.
We also identified an anti-murine/human IL-1RA mAb that potently neutralized IL-1RA in vitro, indicating that targeting of a single IL-1RA peptide epitope is able to directly inhibit IL-1RA activity.
The reduction in liposomal DOPE content did not significantly reduce US-mediated DXR release in vitro, indicating that DOPE is a potent modulator of sonosensitivity.
Deletion of the first 35 amino acids of the variable N-terminus led to a substantial decrease in the overall extent of phosphorylation in vitro, indicating that the N-terminus peptide is the preferred site of PKC phosphorylation.
The important role of the hepatic ECM was demonstrated in vitro, indicating that hepatocyte phenotype is dependent on the nature of the ECM upon which it is cultured [1].
Culture media containing the untagged mature peptide significantly inhibited ecdysteroid secretion by YOs from land crab and green crab (Carcinus maenas) cultured in vitro, indicating that the Gel-rMIH was biologically active.
Two individuals, one binary combinations, and three uniform design (UD) mixtures of the pesticides were found to have significant cytotoxic effects, along with significant time- and dose-dependent induction of caspase-3/7 activity in vitro, indicating that cytotoxicity caused by these pesticides might be attributed to the pro-oxidative and apoptosis induced potential.
Extensive data are available on the importance of the insulin-like growth factor (IGF) system in growth regulation of breast cancer cell lines in vitro, indicating that the IGF-I receptor (IGF-IR), IGF-I (and IGF-II) function as survival factors, while IGF binding protein (IGFBP -3 may act as a growth IGFBP -3r.
In that study, thymocytes from diabetic mice that expressed lower VLA-5 and VLA-6 levels did not show altered migration ability in vitro, indicating that only lower integrin expression on the cell surface is not sufficient to hinder migration.
Purified ScYop1p, when reconstituted into proteoliposomes, leads to the generation of membrane tubules in vitro, indicating that Yop1p is sufficient to induce high curvature in membranes (Hu et al., 2008).
The expression pattern of Opa proteins was consistent after subculturing bacteria in vitro, indicating that Opa expression was selected in mice.
