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The enantiomers of most promising derivatives were separated by enantioselective HPLC and in vitro evaluated.
The members of this series were in vitro evaluated using the MTT colorimetric method against one normal cell line and three human cancer cell lines.
All the newly prepared compounds (3a-3m) were in vitro evaluated for their antiproliferative activity against three human cancer cell lines, namely Colon cancer (HCT-116), gastric carcinoma (MGC803) and hepatocellular cancer (Huh7).
All the newly prepared hybrids (5a o, 8 and 11a d) were in vitro evaluated for their anti-proliferative activity against three human cancer cell lines, namely HepG2 hepatocellular carcinoma, A549 lung cancer and MCF-7 breast cancer.
In the search for new therapeutic tools against Chagas' disease (American Trypanosomiasis) four novel mixed-ligand vanadyl complexes, [VIVO(L2-2H)(L1)], including a bidentate polypyridyl DNA intercalator (L1) and a tridentate salycylaldehyde semicarbazone derivative (L2) as ligands were synthesized, characterized by a combination of techniques, and in vitro evaluated.
In the search for new therapeutic tools against tuberculosis two novel iron complexes, [Fe(L H 3], with 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives (L) as ligands, were synthesized, characterized by a combination of techniques, and in vitro evaluated.
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Here, we isolated and characterized VR-EPCs from cardiac tissue in vitro, evaluating their regenerative potential in vivo.
Their immunomodulatory properties were initially assessed in vitro, evaluating their effect on lipopolysaccharide (LPS -induced cytokine reLPS -induced-1 cytokine
VEGF is a key mediator in tumour angiogenesis, and for this reason, we examined pK1-5 effects on VEGF expression in vitro, evaluating both inflammatory and angiostatic capacities of pK1-5 mediathroughough VEGF.
An association between obesity, particularly in patients with type 2 diabetes, and elevated concentrations of PAI-1, led to studies in vitro evaluating the effects of insulin and precursors of insulin on expression of PAI-1.
Furthermore, the biological activity of these drugs was measured both in vitro, evaluating the TF-1 cell proliferation rate, and in vivo, using the innovative experimental animal model of the zebrafish embryos.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com