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Often, however, results seen in vitro do not adequately represent the situation in vivo.
However, despite the fact that hepatocytes proliferate in vivo during liver regeneration, they are resistant to proliferation in vitro, do not tolerate sub-culture and tend to enter a de-differentiation program that results in a loss of hepatic function.
In addition rat primary hepatocytes in vitro do not necessarily mimic perfectly human liver in vivo.
However, sometimes the data generated in vitro do not agree with the results attained in vivo [10], [25].
Although preliminary data suggest that cell transplant populations differentiated from hESCs in vitro do not express an immunogenic HLA profile [16], the long-term immune effects are unknown.
Current experimental models to study tau pathology in vitro do not usually recapitulate the tau expression pattern characteristic of adult human brain.
Similar(29)
The fibrolytic enzyme that appeared most promising in vitro did not affect lactational performance when fed to dairy cows.
However, the low failure torque tested in vitro does not always preclude successful fracture healing and a good clinical outcome.
The results of these studies showed that differences in antigen production and IFN induction in vitro did not correlate with large changes in immunogenicity in vivo.
Since hormone data secreted by placental tissue in vitro did not differ (P≥0.05) by breed or range of days of pregnancy, data were pooled and analyzed by a One-Way ANOVA.
However, phosphorylation by cyclinB/Cdk1 in vitro did not affect the catalytic activity of SIRT1.
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