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Assembly studies in vitro demonstrated that the compounds could potently disrupt CA assembly with a dose-dependent manner.
Measurement of platelet binding activity in vitro demonstrated that RGD-SAK had a much higher affinity with platelets than SAK.
Studies in vitro demonstrated that high-dose remifentanil suppresses the release of cytokines from neutrophils and monocytes that had been stimulated by LPS [8].
The cell proliferation assay in vitro demonstrated that most target compounds had inhibition potency on both c-Met and VEGFR-2, especially compound 9h, 12b and 12d.
The cell proliferation assay in vitro demonstrated that most target compounds had inhibition potency both on c-Met and VEGFR-2 with IC50 values in nanomolar range, especially compound 12j and 12m.
Furthermore, we designed and transfected miR-592 mimics or inhibitors into the corresponding CRC lines, and our experiments in vitro demonstrated that miR-592 could promote cell proliferation, wound healing and invasion ability of CRC cells (P < 0.05), while miR-592 did not influence the CRC cell apoptosis (P > 0.05).
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Our study in vitro demonstrates that four amino acid neurotransmitters inhibit the formation of reactive carbonyl intermediates during oxidative stress and react with MDA to form different conjugated complexes.
However, regional gene expression patterns are maintained in vitro, demonstrating that some aspects of regionally identity are maintained in vitro.
The monocyte functional studies in vitro demonstrate that 0.5 10 nM levels of the fragment have significant chemotactic activity.
Indeed, light-stimulated Slc9a10-null/bPAC sperm were able to fertilize oocytes in vitro, demonstrating that optogenetics can restore fertility.
Our studies in vitro demonstrate that sialophorin targeting increases the homotypic adhesion of breast cancer cells, reduces transendothelial migration and increases susceptibility to apoptosis and NK cytotoxicity.
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