Comparison of in vitro data with ex vivo data suggested reliability of the advanced buccal in vitro model.
It was possible to correlate the in vitro data with patient response to therapy and the incorporation of [14C] thymidine and [3H] tritiated thymidine by slices of their tumors.
In the same time, it was possible to correlate the in vitro data with patient response to therapy and the incorporation of [3H] tritiated thymidine and the [14C] thymidine by slices of their tumors (Baserga and Lisco 1963; Wimber and Quastler 1963).
This is the first report of in vitro data with chimeric human topoIIs.
Thus, overall, in vivo IL-10 data confirms our in vitro data with macrophages, showing a significant increase in mice exposed to mosquito saliva.
The 5TMM model hereby offers a suitable model combining these in vitro data with in vivo work.
This has been confirmed by in vitro data with human Grx2 where mutant and wild-type rates became equivalent at high glutathione concentrations (cf. Figure 3B, [ 16]).
The authors either need to molecularly link this to differentiation or overcome the hurdles for bolstering the in vitro data with in vivo gene expression data.
