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Similarly to BES10, this site was not tagged with a drug selectable marker and therefore, activation in vitro could not be assessed.
These data suggested that hSKP senescence in vitro could not be prevented simply by the change of culture method.
Formation of biofilm (in vitro) could not be correlated with the presence of described and putative biofilm-associated genes such as esp and asc-10.
The effects of ZD6474 on rat brain endothelial cells in vitro could not be translated to a decrease in MVD in vivo in the present study.
It should be mentioned that PSA measurements in vitro could not be simply extrapolated in vivo since the patients' data also reflect the disruption of the basement membrane.
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In particular, very promising in vitro studies could not be translated in vivo at preclinical stage and beyond.
Accordingly, physiological levels of RA (1 10 nM) could induce Cyp26b1 expression in naïve T cells upon activation in vitro, but could not do so in the presence of TGF-β.
Tumor-infiltrating dendritic cells from PC61-treated or untreated mice induced the proliferation of allogeneic T cells in vitro, but could not induce proliferation of OVA-specific OTI and OTII T cells unless specific peptide antigen was added in culture.
These in vitro effects could not be detected in vivo under the conditions described above.
In vitro experiments could not accurately represent the dynamic setting encountered in vivo.
Correlation to the in vitro models could not be performed as the majority of these are poorly characterized.
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CEO of Professional Science Editing for Scientists @ prosciediting.com