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The in vitro brain and plasma protein binding of GSK1034702 was determined across a range of species using equilibrium dialysis.
Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study.
The in vitro brain and plasma protein binding of GSK1034702 across a range of species was determined using equilibrium dialysis as described previously [2].
In vitro brain distribution of [11 C]N-methyl-SSR504734 was tested in whole-hemisphere autoradiography (ARG) on human brain slices.
When studying in vitro brain slices, rapidly applying multiple agonists, antagonists, drugs, or modulatory compounds is a significant technical problem.
In vitro brain slice electrophysiology is a powerful method to investigate the network and cellular bases of brain function.
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By electrophysiological analysis of postnatal juvenile and adult mouse SN DA neurons in in vitro brain-slices, we observed that D2-autoreceptor desensitization is reduced with postnatal maturation.
Much of current knowledge has been obtained from studies of in-vitro brain slices.
However, we worked in vivo, while Rosay et al., worked on an in-vitro brain preparation.
It has been shown that small nanoparticles can translocate through and accumulate in an in vitro blood brain barrier model composed of rat brain microvessel vascular endothelial cells [10].
Human Polyomaviruses have been shown to possess transforming abilities in vitro, induce brain tumors when inoculated into the brain of experimental animals and are suspected to participate in the oncogenesis in humans (2).
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