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Compounds 14a, 16, 18c, 26c, 35a, and 35b were further examined for their inhibition activity against human FXa in vitro and rat venous thrombosis in vivo.
In 80% human plasma (in vitro) and rat blood (in vivo) also 96.35% and 91% release of rhein and 78% and 86.41% release of boswellic acid respectively was observed.
Though isolated rat dural arteries do not respond to PACAP or VIP in a wire myograph system, PACAP1 27, PACAP1 38, and VIP show equipotent effects in studies performed on human middle meningeal arteries in vitro and rat dural arteries in vivo.
We recently evolved several novel AAV capsids that efficiently transduced both primary human astrocytes in vitro and rat astrocytes in vivo using highly diverse AAV libraries (>107) [14].
The transduction efficiency of LV constructed with the green fluorescent protein (GFP) gene (LV-GFP) was evaluated in bladder cancer AY-27 cells in vitro and rat urothelium via intravesical instillation in vivo.
Previous studies show that the b-catenin-TCF4 transactivation complex regulates GLCE expression in human colon cancer cells in vitro, miR-218 directly represses expression of GLCE in DLD human colon cancer cells in vitro and rat retina in vivo, and that overexpression of the EJ-ras oncogene decreases D-glucuronosyl C-5 epimerase mRNA levels in rabbit endothelial cells.
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This study was designed to examine the effects of a melamine cyanuric acid mixture on cytotoxicity in vitro and rat-acute nephrotoxicity.
It has been shown to both protect against glutamate toxicity in rat hippocampal neurons in vitro and in rat models of traumatic brain injury in vivo[ 6, 7] and promote neurite outgrowth in vitro[ 8, 9].
The flesinoxan dose corresponded to ≈40% occupancy, which based on extrapolations from in vitro human and rat affinities and ex vivo occupancy measurements in rats, in principle should be attainable by vortioxetine in clinical settings.
Among these factors, we describe the over expression of FGF2 in sheep oocytes and FGFR1-2-L1 receptors in GCs that may influence primordial follicle development in accordance with in vitro goat and rat studies [ 51, 52].
Open TG-GATEs (http://toxico.nibio.go.jp/english/index.html) is a public database consisting of in vivo (rat) and in vitro (human and rat) clinical, pathological and expression data for approximately 170 toxic compounds from the National Projects of Toxicogenomics in Japan, generated from liver and kidney.
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