Sentence examples for vital substrates from inspiring English sources

Anesthetic agents alter microcirculation, influencing tissue oxygenation and delivery of vital substrates.

Active caspases cleave vital substrates in the cell, such as actin, actinin, β-myosin heavy chain, myosin light chain, tropomyosin, and cardiac troponins, leading to cellular demise [ 76].

There is persuasive evidence, including the present report by Dubin and colleagues, of a dissociation between increases in arterial pressure produced by vasopressor agents and improvement in microvascular perfusion and delivery of vital substrates.

Following activation of the initiator caspase-8 or -9, the two pathways converge on the activation of caspase-3, which finally execute the death process by cleaving various vital substrates required for cell survival and maintaining the integrity of the genomic DNA [ 5].

Haemolysis also releases arginase 1 into plasma, depleting the vital substrate for NO production, arginine [ 42].

The development of targeted therapies against mTOR, a vital substrate along this pathway, led to the approval of allosteric inhibitors, including everolimus and temsirolimus, for the treatment of breast, renal, and pancreatic cancers.

PMCAs are vital caspase substrates for the subroutine of the death program leading to secondary necrosis.

These findings suggest that metformin may exert its anti-cancer effects by inducing alterations in glucose and lipid metabolism that ultimately deprive cancer cells of vital growth substrates.

Apoptosis is conserved among all metazoans and in vertebrates two main signalling pathways converge at the level of shared cysteine-dependant aspartic acid-specific proteases, known as caspases, that execute cell death by the cleavage of vital cellular substrates.

This complex then activates caspase-9, which promotes the activation of caspase-3 (mean PONDR FIT score of 0.303), caspase-6 (mean PONDR FIT score of 0.233), and caspase-7 (mean PONDR FIT score of 0.221), leading to the subsequent cleavage of vital death substrates and culminating in cell death.

The two domains of sACE contain many conserved residues, which are vital for substrate and inhibitor binding (Table 4).