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DNA polymerase β (Pol β) is a 39-kDa enzyme that performs the vital cellular function of repairing damaged DNA.
Due to the vital cellular function and ubiquitous expression of DHFR, inhibitors of this enzyme have been used clinically in the treatment of a range of diseases [39].
Despite this loss of catalytic activity, the structure of the core exosome is highly conserved from archea to humans, suggesting that the complex performs a vital cellular function.
TPI not only provides a vital cellular function, but also is found in virtually all living creatures.
These cell organelles play a vital cellular function, which is required in the fine-tuning of the posttranscriptional regulation by an alternative pathway [ 13].
Homologs of these genes in other species have been shown to be involved in recycling non-essential proteins and the utilization of the degraded products to maintain vital cellular function [ 52].
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Protein oxidation is known to compromise vital cellular functions.
Biomembranes undergo extensive shape changes as they perform vital cellular functions or become diseased.
Heat shock proteins (HSP) perform vital cellular functions and modulate cell response pathways to physical and chemical stressors.
Lipid peroxidation is obviously the most crucial that leads to alteration in cell membrane which eventually disrupt vital cellular functions [54].
To further investigate the effect of the modified protein on vital cellular functions (Yu et al., 2014), a cell viability assay was utilized (Liu et al., 2011).
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