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And finally, we find no effects of TRA alone (without prior MD) on ocular dominance or visual responsiveness (Fig. S3A D), and no acute effects of TRA administration on visual response properties of V1 neurons (Fig. S3E).
Of 12 putative survival skills and composite variables that summarized all putative skills, only visual responsiveness (proportion of stimulus presentations responded to) was significantly correlated with escape potential.
Visual responsiveness was tested behaviorally using an 8-choice maze placed over a CRT computer screen.
Previous work with these animals has shown that despite having an intact retina, they lack significant visual responsiveness [49].
Mutations in the memory genes dunce and rutabaga increase visual responsiveness to moving gratings in an optomotor maze [3].
We therefore tested 36 long-term memory (LTM) mutants for visual responsiveness to moving gratings in our optomotor maze paradigm (Figure 1A).
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Brain scans (FMRI) illustrated that participants' visual cortex responsiveness was heightened to auditory and tactile sensory input after only five days of blindfolding for over an hour each time.
This suggests a role of ACh in facilitating visual stimuli responsiveness through mechanisms comparable to LTP which involve nicotinic and muscarinic receptors with an interaction of NMDA transmission in the visual cortex.
After monocular deprivation during early life in transgenic animals lacking one isoform of GABA, no variation of visual cortex responsiveness was observed [ 59].
These behavioral results are consistent with our view that the mushroom bodies are involved in visual suppression; optomotor responsiveness increases (and 20 30 Hz brain responsiveness decreases) when mushroom body output is compromised.
This is a normalized ratiometric index analogous to that used to describe front-to-back differences in visual salience responses [18], that uses a normalization by the mean responsiveness of each fly.
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