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Thus, achieving a detailed understanding of mouse visual circuit architecture is of paramount importance.
If halorhodopsin were expressed specifically in OFF bipolar cells, that component of the visual circuit could be restored as well.
Because the mice's photoreceptor cells were completely absent, the researchers targeted the next layer of cells in the visual circuit, called bipolar cells.
Here we review recent progress in understanding the development of retinofugal pathways and how this information is important for improving visual circuit regeneration.
Axon guidance cues and a growing list of other molecules, including immune system factors, have also recently been implicated in visual circuit wiring.
This field is therefore positioned to reveal new principles of visual circuit development that no doubt will extend to other regions of the CNS.
Similar(28)
Nikolaou, N. & Meyer, M. P. Lamination speeds the functional development of visual circuits.
Here, we show that early developmental refinement of visual circuits is perturbed in mouse models of Down syndrome.
Direction-selective neurons, which respond selectively to motion in one direction, have been characterized in visual circuits across many species.
Thus, altered developmental refinement of visual circuits that occurs before sensory experience is likely to contribute to visual impairment in individuals with Down syndrome.
Intra-ocular injection of photoswitches can restore learned light avoidance and pupillary constriction, indicating reconstitution of signaling through visual circuits in the brain.
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