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If patients did not return for one or multiple protocol visits, values for study variables (e.g., systolic blood pressure, antihypertensive drug use) were carried forward from the last available visit.
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The baseline (or screening) visit values for items (0 = wrong; 1 = right) and total scores were obtained for individuals participating in the study on two tests; these were chosen because: a) they were recorded in the data files at the item level; and b) they represent a 'global' and a more 'specific' measure, so that we might observe different results for IIV derived from the items in each.
The first-visit values for the whole sample and the subsample returning for a second visit were 5.3 and 5.1 μg/day, respectively.
In order to be included in these analyses, patients were required to have a final visit value for each metabolic syndrome diagnostic criteria.
In one, the patients' last visit value for a given parameter can be extrapolated linearly to the end of the study period.
Of the 2,190 patients in the metabolic syndrome subgroup, 2,003 patients had a final visit value for all metabolic syndrome criteria (with the exception of waist circumference since baseline values were carried forward).
For patients with one missing visit, values from the previous visit were carried forward to impute the values of the missing visit.
In the case of an event occurring between two consecutive follow-up visits, the values for the time-varying variables measured at the visit preceding the event were used.
Student's paired t-tests were used to determine significant differences between visit 1 and visit 2 values for height, BW, BMI, BF%, BP and resting HR.
Figure 1 illustrates the number of visits, by INR values, for all visits made by the 1,257 patients.
At visit 4, the values for the mean, standard deviation, and median for each of the six component reactions were all less than 1.
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