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The use of a reference score value can be confined to the same value from the visit of addition by considering which Contrast-value should be applied within the visit of addition, from a theoretical point of view.
This zero value reflects no change in score value between the post-treatment visit and the treatment visit of addition.
In contrast, two reference values have been used for an added reference item, i.e. (1) the pre-treatment score value for the Contrast-value at the visit of addition and (2) the score value from the visit of addition (visit of detection) for Contrast-values at subsequent visits (the second situation is equivalent to that of basic reference items).
The positive Contrast-value will decrease to zero when the patient does not improve for that item, and will have a negative value when the patient has improved at a visit following the visit of addition.
The top half of Table 5 shows the TDC-values when the initial Contrast-value of added reference items at the visit of addition was calculated with respect to the baseline according to equation (1).
On the other hand, the Contrast-value is not +1 but zero in the mode of continued added items (no separation of item information between treatment and post-treatment period), with respect to the score value at the visit of addition during treatment (=(4 – 4)/(4 + 4)).
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For a patient who underwent the intensified treatment in the ADDITION study and did not change it after the end of ADDITION, this visit provides him/her the opportunity to choose a less intensive treatment.
Additionally, patients with comorbid relevant psychiatric or medical conditions were not included as evaluated by a detailed first time visit of 1 h in addition to Hamilton anxiety and depression scales as well as Beck inventory.
The final and exit visit was at week 24 and was a repeat of the first visit in addition to a compliance assessment.
With regard to metabolic and immunological measurements, the blood will be drawn at the baseline visit, in addition to measurement of waist circumference, body mass index and blood pressure.
They show a common pattern of results with no differences between intervention and comparison groups over time in increase in child caries experience, dental visits or addition of sugar to children's drinks.
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