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The visible progression of decomposition outdoors was characterized by a brown to black discolouration at stage 5 and remnant desiccated black tissue at stage 7.
Alongside those more visible shifts is a less visible progression of sophisticated machine-to-machine interactions, with no human intervention required.
The photo-based detection rate of visible progression of high risk early AMD in the AREDS and CHARM Studies was about 5% per year (AREDS 2001; Tikellis et al 2007).
Although a rising tumor marker may be detected sooner than radiologically visible progression or than symptoms, available data do not indicate that this approach would lead to improved survival in patients with metastatic breast cancer.
Taking into consideration the radiogeometric assessment of RA progression, the results from the study conducted by van der Heijde and colleagues in 128 patients with a mean leflunomide treatment duration of 4.3 years demonstrated no radiographically visible progression in 33% of the RA patients during the leflunomide therapy [ 23].
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No clear differences were seen in the distance of visible disease progression through the silique and pedicel between genotypes (Additional file 1: Figure S1).
In some cases, such as Eucalyptus marginata and P. cinnamomi, plants may be artificially inoculated in the field (Stukely et al. 2007), or, as in Fraxinus excelsior and Hymenoscyphus pseudoalbidus, natural infection rates may be sufficiently uniform with visible disease progression so as to allow assessment of resistance directly in transplanted seedlings within a few years (Kjaer et al. 2012).
What they do have in common, though, is a highly visible sense of progression.
E9802 was a phase 2 multi-institution study conducted to evaluate the safety and effectiveness of vaccinia and fowlpox prostate-specific antigen (PSA) vaccine (step 1) followed by combination with androgen ablation therapy (step 2) in patients with PSA progression without visible metastasis.
When following patients on active surveillance, serial MP-MRI scans are critical during follow-up to detect progression of visible lesions over time.
Stevens show that, in a series of 108 men, 45% of those with a visible lesion showed radiological progression compared with 17% of those with no visible lesion at baseline [ 45].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com