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However, it is very easy for viruses, especially RNA viruses, to develop resistance against such drugs due to the high mutation rates of the viral genomes.
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"It would be very difficult for the virus to develop resistance against a therapy that targets a cellular protein," says Palese.
Unfortunately, high genetic variability of HIV in combination with selection pressure introduced by drug treatment enables the virus to develop resistance against this drug class by developing point mutations.
Previous research has, however, shown that it is quite easy for influenza A virus to develop resistance to oseltamivir [24], [25].
On the other hand, targeting a host factor rather than a viral protein might make it more difficult for a virus to develop resistance against the drug [8].
This may enable the virus to develop resistance to the drug.
Targeting key host factors, on the other hand, may be a more tractable approach, as it should be more difficult for a virus to develop resistance.
Furthermore, the sequenced cultivar SunUp is the transgenic line containing coat protein of Papaya Ringspot Virus (PRSV) to develop resistance against the virus [ 46, 47].
Poor quality drugs can allow bacteria, viruses or parasites to develop resistance and that can undermine the efficacy of the high-quality medicine.
However, the viruses' dynamic ability to develop resistance against these agents necessitates the investigation of novel targets for viral suppression.
However, due to a high mutation rate, this virus is capable to develop resistance to existing drugs causing the treatment failure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com