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It is protective by ensuring maintenance of virus latency after infection, yet deleterious by recruiting and activating microglia that secrete potentially damaging factors at sites of brain injury.
The majority of strategies to eradicate HIV have been based on preventing virus latency, thereby enabling antiretroviral drugs to act against HIV replication.
During virus latency, the virus is present in a stably suppressed state.
Partial cell activation and proliferation could be one of the mechanisms by which IL-7 acts on virus latency [45].
It also seems to be implicated, together with SP1 and SP3, on the establishment or reactivation of varicella-zoster virus latency [233].
Therefore, we performed several passages of the viral progenies to new turnip plants using sap-inoculation and, after each passage, monitored virus latency periods (Fig. 2).
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In contrast to the herpes simplex virus, the latency of VZV is poorly understood.
As the virus establishes latency, limited immunodominant epitopes arise.
The virus establishes latency in the nerve ganglia.
Prostratin, like other PKC activators induces virus from latency through the activation of the transcription factor NF-κB [ 10].
The delicate balance between virus replication, latency, and the extent of activation of the DDR ultimately dictates whether an infected cell will give rise to a productive cycle generating progeny virions or a tumour.
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