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Suguitan et al. previously demonstrated that restoring the polybasic cleavage site in the H5 HA of the vaccine virus improved its immunogenicity and efficacy, suggesting that removal of polybasic cleavage site due to safety concerns, had a deleterious effect on the immunogenicity and efficacy of the H5N1 HA [19].
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These findings indicate that immunization of mothers with a DNA vaccine against the influenza virus improves the ability of their offspring to develop protective immunity against viral challenge post vaccination.
Similarly, repeated infection with seasonal influenza viruses improves protection and clearance of 2009 pandemic influenza in ferrets[ 11].
Management of infection with human immunodeficiency virus (HIV) improved dramatically during the 1990s.
Their team cloned the genes for fragments of binding region of the mouse anthrax antibody in a virus and improved their affinity for PA by repeatedly generating variants and picking out the ones that bound PA best.
Through nuclear-derived diagnostic kits, detection of the Ebola virus was improved radically from several days to a few hours.
Understanding the genetic changes in this virus that improved its replication phenotype is an area of current investigation.
Our results also imply that NEIBMs with a high affinity to IgM could have potential application for detection of antibodies against other viral infections, such as hepatitis E virus or dengue virus, to improve of detection efficacy and early diagnosis.
Our studies indicate that serial lung passages of the WT702 virus in quail improved the virus's ability to replicate in chickens, where it was partially transmissible.
Additionally, performance of anti-virus is improved outside of the virtual machine.
Outbreak investigation methods for enteric viruses were improved in 1990s when gene amplification techniques were established in viral laboratories.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com