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The role of DltR/DltS in S. agalactiae virulence was shown by the attenuated virulent properties of dltA and dltR mutant strains in vivo [11].
Quoting scientists at the University of Münster, the institute rebutted earlier reports that the newest strain of E. coli had never been previously identified, calling it a "hybrid clone" that drew together the virulent properties of other strains.
It also controls the virulent properties of S. agalactiae.
Finally, Sak189, but not Sak188, controls virulent properties of S. agalactiae in vivo.
Murine intraperitoneal model of streptococcal infection was developed to compare the virulent properties of the strains under study.
Finally, insertional inactivation of sak189 gene, but not sak188 gene, significantly affects virulent properties of S. agalactiae.
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EPS productivity is known to enhance the virulence properties of otherwise innocuous or relatively low virulent bacteria [ 7, 8, 16, 17].
It could be predicted given that inactivation of other S. agalactiae TCSs (CovS/CovR, DltR/DltS, RgfA/RgfC) resulted in the changes of virulent properties, however, in all these studies the mutant strains became less virulent compared to the wild-type strains [8] [12].
S. aureus is a unique pathogen because of its virulent properties, its protean manifestations, and its ability to cause endocarditis on architecturally normal cardiac valves.
Compared to the wild-type strain, the differences in virulent properties were statistically significant in case of sak189/sak188 double mutant strain (P-value <0.02), and not significant in case of sak188 mutant strain (P-value = 0.73).
To investigate whether genomic variations among P. acnes strains can explain their differences in virulent properties, in this study we performed a detailed genome comparison of the genome of HL096PA1 to KPA171202.
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