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A similar agr locus was also recently implicated in Listeria monocytogenes virulence, where agrD-dependent quorum sensing regulates biofilm formation, Caco-2 cell invasion and mouse virulence [36].
As mentioned in the Results, a similar agr locus is well-established in quorum sensing regulation of S. aureus virulence, where the agr locus controls expression of several toxins, as well as some surface virulence factors [20].
The intracellular survival and replication of Brucella is considered the essential trait of virulence where the Brucella-containing phagosomes avoid bactericidal mechanisms by evading fusion with degradative lysosomes, a process which is mainly orchestrated by the type IV secretion system VirB [ 2, 3].
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Our model shows that optimal virulence occurs where these elasticities are equal (Figure 7a).
These results conform to standard virulence theory where there is a relationship between transmission and virulence, such that intermediate levels of virulence evolve.
PagK was first identified as a PhoP-activated virulence gene, where Tn phoA insertion decreased Salmonella virulence significantly in mice [ 37].
Within the virulence repertoire, where recombination could be identified, it was generally present among all isolates within a single PG s), indicating that the recombination was likely to be ancestral occurring prior to PG divergence.
Less severe infections may be caused by LCC-negative strains where virulence is facilitated by other virulence factors, some of which we identified in strain ATCC9714.
These cases where virulence is obviously of no selective value (neutral) [16] led to the hypothesis of coincidental evolution of virulence factors.
Melanoma is a tumor where virulence is conferred on transition from flat (radial) to three-dimensional (tumorigenic) growth.
The same situation occurs in the case of the Shigella flexneri virulence plasmid pWR100, where the second parB-like gene, virB, is required for transcription of a subset of virulence genes [13].
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