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T. congolense IL1180 is a relatively low virulence strain with long survival times after infection.
Specifically, melanin production, capsule size, cell wall integrity and fertility were higher in strain R265 than in the low virulence strain R272.
As strain R265 showed higher melanin synthesis, capsule production and higher cell wall integrity/growth at 37°C, the highly expressed genes (Table S2) potentially responsible for these major virulence factors were characterized in the high virulence strain, R265.
Nine of the strains were chosen to represent the four major clades of C. albicans strain types [36], with one high virulence and one and low virulence strain chosen from each clade from among 43 isolates tested in a separate study [37].
Significant up-regulation of three IFN-γ-induced genes in the MRLNs of pigs infected with the low virulence strain was the only clear qualitative difference in gene expression observed between the strains with high, moderate and low virulence.
However, our model predicts an MDV prevalence before slaughter of between 25 and 100% for a medium virulence strain (02LAR, v = 46 ), which would be persisting at extraordinary high concentrations within the barn.
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Recently, in an attempt to identify chromosomal variations underlying the different properties of high versus low virulence strains, the genome of the highly virulent strain 8081 [ 12] has been compared to genomes of low virulence strains [ 13, 14].
Visualization of bands of iap (457 bp) and gyrB2 (711 bp) genes after PCR amplification referred the presence of virulence strains of Listeria spp. and Klebsiella spp., respectively in the export quality shrimp samples.
Taking advantage of this natural experiment in pathobiology, we utilized the high and lower virulence strains in an attempt to identify key components of the C. gattii virulence composite.
MIG levels in spleen at 48 h were highest for mice infected with the lowest virulence strains, while MCP-1 levels in spleens at 48 h were highest for mice infected with the most virulent strains.
The present whole genome microarray study revealed extensive differences in the transcriptional profiles of representative high and low virulence strains of C. gattii from the Vancouver Island outbreak, the most important of which were confirmed by phenotypic analysis.
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