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Once a significant proportion of a population develops immunity through the production of antibodies capable of neutralizing the new virus, the infectiousness and virulence of the virus decreases.
It is suggested that mutations in the virus will be necessary to prevent mortality, but must be designed carefully so as not to reduce the virulence of the virus.
In conclusion, C to G point mutations, within the BKV NCCR Sp1 binding site, were significantly more common in patients with HC, suggesting that these mutations may be indicative for the clinical diagnosis of HC and could influence the virulence of the virus.
MERS-CoV infection is associated with significant mortality related to the virulence of the virus, nature of the disease, and the lack of effective therapy.
"The possible consequences of further international spread are particularly serious in view of the virulence of the virus," WHO said after a meeting on Friday.
"The possible consequences of further international spread are particularly serious in view of the virulence of the virus," it said after the meeting.
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The size of epidemics and their relative effect reflect interplay between antigenic variation of the virus, protective immunity in the population, and relative virulence of the viruses.
Almost all animals infected with the N569 or A663 strains showed moderate to high levels of viral excretion confirming the virulence of the viruses used.
This selection not only increased virulence of the viruses but also improved their replication potential in their hosts and transmission between the latter via the respiratory route.
To evaluate whether residue 279 could influence the replication and virulence of IBDV, the virus rGxHT-279 with three mutations (Q253H/D279N/A284T) was rescued and evaluated.
The safety test indicated that, when receiving the recombinant virus at a concentration of 106.0 pfu, no virulence of the recombinant virus to the mice, piglets and pregnant sows was observed.
More suggestions(15)
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virulence of the recombinant
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