They found that serine hydrolase expression was generally similar among all cell lines, with two key exceptions: one of the hydrolases was active in normal prostate cells but virtually inactive in all the tumor cells, while another was expressed in all of the tumor lines but absent in the normal cells.
THD was virtually inactive in antagonizing the inhibition of ACh release induced when nomifensine was used to increase endogenous synaptic DA, despite significantly antagonizing these effects on DA release in the same slices.
A double mutation of R25E and R127E showed the strongest effect on RecX-dependent inhibition, rendering the protein virtually inactive in both ATPase and strand-exchange assays at all tested concentrations.
In the presence of PHOS and NEO, Senktide was virtually inactive in both BSM and TSM.
Then the researchers found that in brain cancer cells in the lab, enzymes that typically produce energy were virtually inactive in mutated cells compared with normal IDH cells--suggesting that these cells aren't metabolizing energy as efficiently and have less to grow on.
Tumour lysis mediated by monocyte-derived macrophages depended on the presence of CE7 gamma 2a antibodies; antibodies from the CE7 hybridomas of gamma 2b and gamma 1 isotypes were virtually inactive in ADCC assay.
It has been shown that the α, β-unsaturated carbonyl group may be an important structure of curcuminoids, because THC, lacking this functional group, was virtually inactive in inducing HO-1 expression [ 34].
Except for Hagler, boxing's two biggest attractions now, Leonard and Cooney, have been virtually inactive for the last four years.
The two ChEs may be distinguished functionally both kinetically and pharmacologically: AChE hydrolyzes acetylcholine (ACh) and is virtually inactive on the larger substrate butyrylcholine (BCh).
Thus, repeat 9 was also necessary for fibrinogen binding as shown by the marked enhancement in activity with its addition to the virtually inactive LigB10-12 (Figure 5A).
