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On the other hand the outcome of a RCT may not be generalisable to the common practice because of vigorous selection of patients and institutions.
In contrast, the male-specific genes expressed at either earlier or later stages of spermatogenesis (that is in spermatogonia or in round spermatids) are over-represented on the mouse X chromosome [ 5, 6], consistent with the vigorous selection for male-beneficial X-linked genes proposed previously [ 7].
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This could have been avoided if a more vigorous question selection process had been undertaken, that would include multiple pilot tests, focus groups and interviews to enhance content validity [ 48, 49].
In addition, the selection favored vigorous young males with distinct phenotypes.
In addition, reversion to a wild-type phenotype svt2 might be facilitated by a selection of vigorous embryos into maturity.The sequence changes in the vtc1-1 and svt2 suggests an origin of a 'template' independent of L er and Col alleles, and might also be sequences from another related ecotype.
Another factor that must favour the selection of very vigorous hybrids lies with the number of acorns that an oak produces.
In population ecology, debate over group selection was brief but vigorous; by 1970, most biologists agreed that natural selection was rarely effective above the level of individual organisms.
This result suggested that male male tandem running should result in selection pressure in favor of vigorous males.
Select young and vigorous breeders.
There has been vigorous debate regarding the roles of drift and selection in the evolution of genes, genomes and organisms [71], [72], but the mechanisms by which genomic changes result in evolutionary novelties remain unclear.
For Cd-resisitant S. matsudana selection, only five seedlings showed relatively vigorous growth from approximately 2000 seeds screened, but their following growth was delayed.
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