Once-daily dosing is perhaps best reserved for young, vigorous patients given moderate doses of lithium to limit the potentially toxic impact of high, daily peak serum concentrations.
Vigorous attention to patient outcomes supports the learning of the traditional knowledge, skills and attitudes of the professions but also compels attention to processes of teamwork, and quality improvement, and to enhanced understanding of the nature of, and threats to, patient safety.
"GPs are being advised to apply vigorous tests on patients to see if drugs will be effective before prescribing them; and the health regulator, NICE, has even suggested that soft touch doctors should be sanctioned for over-prescribing.
On the other hand the outcome of a RCT may not be generalisable to the common practice because of vigorous selection of patients and institutions.
A low-salt diet was prescribed for all patients, and no patient performed vigorous physical activities.
The magnitude of perturbation (amount and speed of sudden treadmill belt motion) was set for each trial by the therapist from level 1 (mildest) to level 5 (most vigorous) based on each patient's day-to-day and trial-to trial performance.
There were 222 (77%) patients with classic achalasia and 66 (23%) patients with vigorous achalasia.
There exists a significant cohort of patients with a minimal cytokine response that died, and a smaller cohort of patients with vigorous and sustained response, that survived.
All the patients required vigorous physiotherapy before and after frame removal to achieve good range of motion in the knee and ankle.
Although potentially benign, this myopathy is life-threatening in the first months of life and patients require vigorous life-sustaining measures.
