Sentence examples for vigorous activation of from inspiring English sources

Further, an in-depth molecular analysis highlighted the early and vigorous activation of the PPARγ transcription factor-cascade in adipose-derived MSC that resulted to be both delayed and reduced in foetal MSC accounting for their lack of adipogenic potential.

We postulate that the immunosuppression is generated as a consequence of the induction of the Treg system in host, in order to limit collateral tissue damage potentially provoked by a virus-induced vigorous activation of immune responses.

The cytokine signature produced by the untreated bovine and porcine samples is consistent with vigorous activation of cells of the innate immune system.

It has been demonstrated that in many breast cancers the effect of therapy can be abrogated by high levels of ErbB-2 and vigorous activation of the phosphatidylinositol 3-kinase (PI3K) pathway [ 13].

Importantly, CD40L but no other maturation stimuli (inflammatory cytokines, CpG DNA, poly(I C), lipopolysaccharide) induced both a vigorous activation of DCs and the robust functional maturation of immature APCs, as shown by the upregulation of the antigen-presenting machinery, the secretion of IL-12 and enhanced T cell stimulatory capacities.

In addition, TAP binding protein, another molecule involved in MHC class I antigen loading [ 44, 49, 51, 53], and MHC class I complex ZE protein were also up-regulated in WED-immunized zebrafish liver, strongly suggesting a vigorous activation of the MHC-I processing pathway.

Hyporesponsiveness of SF-derived CD4 T cells upon mDC or TSLP-mDC stimulation was robustly reversed by IL-7, which is in line with previous data demonstrating vigorous activation and even hyperresponsiveness of synovial CD4 T cells in the context of monocytic cells [ 19].

Schedule vigorous activities for cooler times of the day.

There is evidence suggesting that Vα i NKT cells naturally influence autoimmunity and from other experiments it appeared that a vigorous but unnatural activation of Vα i NKT cells by α-GalCer is required to elicit their regulatory function.

The same gene variants which result in rapid activation of a vigorous inflammatory response to infection may have the disadvantage of increasing the risk of auto-immune and inflammatory diseases later in life [8], [9].

It was found that activation of the surface via vigorous hydrogen evolution that occurs during porous copper deposition and TCNQ mass transport being hindered through the porous network of the copper template influenced the growth of CuTCNQ and CuTCNQF4.