Suggestions(2)
Exact(7)
Further, an in-depth molecular analysis highlighted the early and vigorous activation of the PPARγ transcription factor-cascade in adipose-derived MSC that resulted to be both delayed and reduced in foetal MSC accounting for their lack of adipogenic potential.
We postulate that the immunosuppression is generated as a consequence of the induction of the Treg system in host, in order to limit collateral tissue damage potentially provoked by a virus-induced vigorous activation of immune responses.
The cytokine signature produced by the untreated bovine and porcine samples is consistent with vigorous activation of cells of the innate immune system.
It has been demonstrated that in many breast cancers the effect of therapy can be abrogated by high levels of ErbB-2 and vigorous activation of the phosphatidylinositol 3-kinase (PI3K) pathway [ 13].
Hyporesponsiveness of SF-derived CD4 T cells upon mDC or TSLP-mDC stimulation was robustly reversed by IL-7, which is in line with previous data demonstrating vigorous activation and even hyperresponsiveness of synovial CD4 T cells in the context of monocytic cells [ 19].
Importantly, CD40L but no other maturation stimuli (inflammatory cytokines, CpG DNA, poly(I C), lipopolysaccharide) induced both a vigorous activation of DCs and the robust functional maturation of immature APCs, as shown by the upregulation of the antigen-presenting machinery, the secretion of IL-12 and enhanced T cell stimulatory capacities.
Similar(53)
Vigorous activity included both vigorous sports and vigorous work.
Vigorous activity without having to go run!
Although the 2011 M9.0 Tohoku-oki earthquake was followed by relatively vigorous remote activation, the reported dynamic triggering thresholds were quite high (Miyazawa 2011), similar to those reported by van der Elst and Brodsky (2010) for Japan.
However, under these conditions systemic hypercapnia still evoked vigorous sympathetic activation and the slopes of the CO2-evoked sympathoexcitatory and cardiovascular responses were not affected by inhibition of C1 neurones.
MVPA: moderate-and-vigorous physical activity; VPA: vigorous physical activity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com