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In the past, it has often been suggested that TEs have detrimental effects, as TEs were often viewed as deleterious parasitic entities [ 6, 38, 91].
Since hypoxemia is generally viewed as deleterious and moderate levels of arterial hyperoxia as benign, health care practitioners are more likely to accept supranormal arterial O2 levels as this provides a wider safety buffer [ 1, 2].
Because the proliferation of transposable elements is generally viewed as deleterious, the number of transposable elements within a genome is hypothesized to be under the control of purifying selection and a decrease in effective population size would inevitably lead to genome expansion (Lynch and Conery 2003).
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Fire is viewed as having deleterious effects on woody and grass species richness (Smart et al. 1985) and that it precipitates the decline of trees by inhibiting recruitment (Nangendo 2005).
In that regard, S alleles can be viewed as slightly deleterious alleles.
ROS have been viewed as mostly deleterious to health and hence aging.
However, most often dispersion is viewed as a deleterious effect that requires compensation, either by optics or numerical post-processing.
Early catch up growth, long viewed as an essential recovery from the deleterious effects of poor growth on development and health, is now recognized as a risk factor for insulin resistance, obesity and type 2 diabetes [ 14].
The targeting of LTR insertion upstream of genes [ 23, 24] (which can be viewed as a means to minimize the deleterious effects of retrotransposition in a compact genome [ 32]) could limit the potential of regulating retrotransposition pre-transcriptionally in S. pombe, as any interference with transcriptional regulation presumably would also affect neighbouring protein-coding genes.
Among these, L-Glutamate (Glu) can be viewed as a toxic species that is potentially deleterious to neurons.NO is a reactive nitrogen species (RNS), while glutathione (GSH) and ascorbate (ASB) are antioxidants that can alleviate oxidative stress.
It is important, however, to recognize that RRT initiation in these circumstances can largely be viewed as 'rescue therapy' where delays may have deleterious consequences for the patient.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com