Photographers like Victor Prevost, who arrived in America in 1848 from France, specialized in views that stressed the aspect of instability and incompleteness.
Although many obstacles remain before single-cell sequencing can be routinely implemented as a standard procedure for detecting genome instability, it has the ability to provide an unprecedented view of genomic instability.
These results allow a global view of genomic instability at a high level resolution (50 Kb on average) and the identification of new gene loci that are recurrently altered.
We have applied one such approach to the surveying of public tumor data to provide a cursory view of genome instability across numerous tumor types.
As for the genomic instability, it originally refers to induced long lasting sub-lethal effect or normal cells turning into cancer while our view of genomic instability is the change of gene regulation that cause abnormal differentiation of original cells, that maybe related to malignant transformation or induced apoptosis.
For example, our approach allowed a prediction of an instability index in 78 different tissues and conditions in the mouse tissue gene expression data set (Table 1), a far greater number than has ever been previously measured, providing a comprehensive view of tissue instability.
The article applies Arend Lijphart's theory of consociational democracy, or elite accommodation, and Robert Putnam's theory of the two-level game to European integration, using these theories as the lenses through which to view growing roots of instability in the European environment: demographic decline, immigration, populism, and educational and labor shortfalls.
This paper establishes the mathematical formalism for the modeling of the mucus layer in the human trachea as a viscoelastic multiphase fluid system with surface tension with a view toward study of instability properties of the air mucus system aimed at improving the design of new bioaerosol suppressing medication.
Therefore, insights into the potential of VX-809 will help improve the efficacy of the drug in targeting CF. ΔF508 CFTR is a temperature-sensitive mutant that can be rescued to the plasma membrane at low temperature (24 30 °C) and when transferred to 37 °C, in view of the high instability of the mutant protein at the cell surface, ΔF508 CFTR becomes internalized and subsequently degraded.
To our knowledge, our study provides the most comprehensive view of the global instability of growth genetic architecture in a forest tree species thanks to a detailed analysis of the temporal and environmental dynamics of growth over the whole rotation period.
