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From a systems biology point of view, alterations (e.g., mutations) in the genes coding for the "hub" protein would not be advantageous as they might lead to partial or complete collapse of the network.
Consistent with this view, alterations in the ISG15 pathway have been identified in human tumours and in tumour cell lines.
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To characterize from a vibrational point of view the alterations caused by aging on human oocytes.
The Records of Necessity were the fundamental, analysed documents which allow to determine the real view of alterations Project Documentation.
The study of snake venom-induced local tissue pathology has been predominantly based on experimental designs and concepts that view tissue alterations from a dichotomous, homogeneous and reductionist perspective.
The observed effects using MDS-MSCs that were expanded in vitro is also striking, as it establishes that in spite of the current view that alterations to MSCs in MDS marrow are most often a secondary adaptation of the disease [3, 6, 23], these transformed MDS-MSCs are self-replicative to propagate biological abnormalities to their progenies and can potentially exert a long-lasting effect in vivo.
The quality of data generated was verified with scatter plots, which provide a graphical view of alterations in the control versus UCH L1 siRNA cell lines, for which the log of mean intensity for each pair of replicates was plotted (Figure 2A).
Furthermore, an in silico pathway analysis provided a global view of alterations in the networks of key regulators of biological pathways that presumably take place in ONC.
Emphasis on genome-wide gene expression analyses has been driven by the general view that alterations in protein-coding oncogenes or tumor-suppressor genes underlie tumorigenesis.
CD18 was shed primarily from intermediate CD14++ CD16+ monocytes, supporting the view that alterations in innate immunity can regulate the inflammatory processes in SpA.
Our data provided a systemic view on alterations in HCC-activated Tregs, which was not only useful in finding new biomarkers but also in further exploring the functions of Tregs in HCC patients.
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