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'vicissitudes' is a correct and usable word in written English.
It can be used to describe the changes or fluctuations of something, often used in a negative or difficult context. Example sentence: I have faced many vicissitudes during this difficult time.
Dictionary
vicissitudes
noun
Plural of vicissitude
Exact(60)
If it takes root, it will outlast the vicissitudes of politics.
There is a lot of talk about the vicissitudes of life, and being equanimous in the face of adversity, all of which I find rather quaint.
"Your progress is measured only in how far you are able to face life's vicissitudes with equanimity, nothing more".
Yet, despite the ravages of time, changing customs, vicissitudes of fashion, the Victorian garden cemetery still survives in its various forms, one of the great legacies of the 19th century.
Although DeMent has made only a handful of albums since her stunning 1992 debut, Infamous Angel, her catalogue of deeply personal songs examining the vicissitudes of family life have left their mark.
A little more able to face life's vicissitudes with equanimity, as Goenka would say.
"We are medicalising common situations: conflict, separation and the vicissitudes of life," said Gladys Mujica Lezcano, a Barcelona-based hospital doctor.
In a sense, it is a problem caused by regulators; they wanted banks to be less exposed to the vicissitudes of markets.
Or do they aim big, covering as many areas as possible, and protect themselves against the vicissitudes of the markets?
But this is a commercial film, and is thus subject to the vicissitudes of public taste.
The species was brought back from the brink (only 30 individuals left in the 1950s) to a point where, while it is still classified as endangered, it seems reasonably safe from the vicissitudes of fortune.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com