There is a vicious circle – new development is poor because it takes so much effort to overcome objections and people object to it because it is poor.
From the beginning of development, Vicious Cycle wanted players on all three consoles to be able to play against each other online.
We proposed the term "positive vitreous pressure glaucoma" to replace "malignant glaucoma" as: i. the phrase "positive vitreous pressure" reflects the final common pathway leading to the development of vicious cycle of increased in transvitreal pressure, ii.
The scant oral intake, as a consequence of his disability, caused progressive undernutrition which closed a vicious circle, delaying his development and his ability to overcome the swallowing handicap.
Third, clinically it is not easy to obtain optimal physiological level of insulin to sustain glycemic control by exogenous insulin administration and therefore hyperinsulinemia is unavoidable in the presence of insulin resistance, leading to a vicious cycle favoring the development of breast cancer.
Interestingly, several of the stimuli are also released in response to LOX-1 activation such as endothelin-1 and TNF-α and oxLDL itself increases LOX-1 expression, suggesting that the LOX-1 axis composes a vicious cycle for the development of atherosclerosis [ 15, 29, 36, 44].
This view changed in the 1970s and 1980s, when migration became more widely seen as being part of a vicious circle of under-development, which widened the gap between core and periphery countries.
Tumor cells present at the bone metastatic site stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone promote tumor growth, leading to the development of a vicious cycle.
Thus, local interactions between tumour and bone cells form a vicious cycle that underlies the development of skeletal metastases.
All these factors are key to reduce the long-term and devastating effects of this vicious cycle on children's development, therefore helping to achieve full human potential.
