Under conventional IHC conditions, although the original concentration was maintained on the tissue in the initial state, the concentration of analyte exposed to the tissue was significantly lower because the analyte in the vicinity of tissue was bound to tissue receptors.
In addition, our data showed that CT45A1 induced CXCR4 overexpression in MCF7-CT45A1 cells and resulted in metastases from in situ breast tissue to lung tissue or to the vicinity of bone tissue.
Elevated pyruvate and lactate signals in the vicinity of prostatic tissues were observed in transgenic tumor mice.
Besides, the nanocarriers for anticancer drugs can also take advantage of the enhanced permeation and retention (EPR) effect [9 11] in the vicinity of tumor tissues to facilitate the internalization of drugs in tumors.
The most highly vascularised areas were invariably observed at the tumour periphery and in the immediate vicinity of normal tissues.
Current PBTK models for BPA do not take into consideration the influence of local deconjugation of BPA metabolites at or in the vicinity of target tissues.
Indeed, because of the close anatomical vicinity of vascularized tissues and avascular compartments, the eye, in which vasoinhibins control ocular angiogenesis, vasodilation, and vascular permeability, is one of the best-characterized target organs for vasoinhibins and represents a key illustrative example of the actions of vasoinhibins (4, 21, 22, 44, 77, 99).
Subcutaneous injections of IL-12@RIG in the vicinity of tumor tissue showed remarkable tumor growth inhibition in tumor-bearing mice, compared to that observed with injection of IL-12 alone, suppressing adverse events caused by IL-12 induced IL-12 induced
Capillaries were counted in panniculus carnosus layer, in the direct vicinity of granulation tissue, at 400× magnification.
Notably, the staining was particularly strong in the vicinity of bone tissue and also in the spindle cells forming the major part of the tumor.
Apart from conceivably underlying immunomodulatory mechanisms, a function as decoy and scavenger receptor for pro-metastatic acting VEGFR-1 ligands from the tissue vicinity might also be possible.
