We have developed synthetic routes one giving a diastereomeric mixture and one enantiopure to vicinal amino alcohol building blocks for application in SPPS.
Furthermore, we can also envisage the application of the vicinal amino alcohol building block in other conditional settings, such as when triggered depletion of effector peptides or ring-opening of cyclic peptides is desired.
In conclusion, the development of a vicinal amino alcohol building block has made periodate-mediated peptide backbone cleavage possible under extremely mild conditions and without accompanying methionine and disulfide oxidation.
The vicinal amino alcohol building block that we present here conveniently solved these problems because the peptide— p*AA incorporating this moiety and loaded into the MHC complex was cleaved at a very low NaIO4 concentration (10 μ m), which precludes Met co-oxidation.
It is unique among the nine mammalian glycan building blocks in that it contains vicinal diols in the form of a glycerol moiety that is relatively unhindered and flexible compared to those found on the other monosaccharides.
EA can inactivate PKC by chelating the zinc and oxidizing the vicinal thiols present within the catalytic domain and block the signal transduction induced by tumor promoters.
The Malcolmson lab has recently shown that gem-difluoroazadienes can serve as a novel building block for the synthesis of chiral alpha-trifluoromethyl amines via the vicinal fluoro-functionalization of its alkene.
We have examined the role played by the two highly conserved vicinal Cys residues in Sx1A TMD on evoked-secretion, using Sx 1A mutants, Sx isoforms, a vicinal Cys block by phenyl arsene oxide (PAO), and a truncated Sx 1A.
In Si 553 -Au and related vicinal Si 553 -Aurfands, this anisotrelatedises naturally at the step edge.
Visinoiu, A. et al. Initial growth stages of epitaxial BaTiO3 films on vicinal SrTiO3 (001) substrate surfaces.
Fusano, A., Sumino, S., Fukuyama, T. & Ryu, I. Vicinal C-functionalization of alkenes.
