Even small gains in replication fidelity are advantageous to the system, if only due to the decrease of the reproduction cost as a result of the increasing yield of viable copies of the genome.
Only flies with homozygous viable single-copy transgenes that have exact molecular mapping data were analyzed.
Given that Ptbp2 heterozygous mice are viable, a single copy of Ptbp2 is apparently sufficient to support development.
The complaints, brought by then-Attorney General Phill Kline, accused Comprehensive Health of Planned Parenthood of Kansas and Mid-Missouri (CHPP) of performing unlawful late term abortions without determining whether the fetus was viable and falsifying copies of abortion reports.
Of the five genes that were used in both studies, Moriya and colleagues found that SWE1, CLB1, CLB2 had a low limit of viable overexpression (<20 copies).
Note the ability of the loss-of-function Kar2-C63D/F/Y/W alleles to rescue the cell death phenotype from Ero1* overexpression was observed at 37°C, the temperature at which none of these alleles are viable as the sole copy of cellular BiP.
Then, while the pre-existing genes kept the species viable, the extra gene copies could evolve new functions, thus speeding evolutionary change.
At the start of each generational round, each cell was viable with two gene copies to bind each set of ligands, as shown in Table 1.
Disruption of either of the S. cerevisiae βNAC copies yielded viable strains, that differ only in the level of GAL1 and GAL10 induction after transmission to a medium containing galactose in stead of glucose [ 15].
If limited to this approach, only regions with one of three types of allelic copy number are viable candidates for the temporal analysis.
