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During ground tracking exercises, we covered the entire island of BCI via trails or from a boat going around the shores of the island (Fig. 4).
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Two of the Via Alpina trails — the Red and the Purple — go through the park, and my plan was to switch from one to the other at a junction above the Soča Valley, then circle under the summit of Triglav to the mountain hut of Koča na Doliču.
Lactastatin induced cytosolic accumulation of p53 and enhanced apoptosis via TRAIL-R2 (DR5) [ 72].
Furthermore, in this ex vivo model, TRAIL combined with doxorubicin induced significantly more apoptosis via TRAIL-R1 than TRAIL-R2.
In line with those results, on Colo205 cells, which trigger apoptosis preferentially via TRAIL-R2, TRAIL-R1 is undetectable.
We found cancer cell-specific differences with regard to their propensity to undergo apoptosis via TRAIL-R2 or TRAIL-R1.
Instead, a group of pancreatic cancer cells have a higher propensity to undergo TRAIL-induced apoptosis via TRAIL-R2.
AsPC-1, BxPC-3 and Panc1 cells elicit apoptosis via TRAIL-R2, whereas Colo357 cells and PancTu1 cells preferred TRAIL-R1 to induce cell death.
These findings are in line with our previous findings and underline that pancreatic cancer cells undergo apoptosis preferentially via TRAIL-R1.
Furthermore, given the importance of TRAIL-R2, we hypothesized that the use of TRAIL-R-specific variants that specifically induce apoptosis via TRAIL-R2 might increase the efficacy of the MSC.sTRAIL system further.
Our results show that some pancreatic cancer cells use TRAIL-R1 to induce cell death, whereas other pancreatic carcinoma cells such as AsPC-1 and BxPC-3 cells trigger apoptosis via TRAIL-R2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com