Contraction of ECM by skin and lung fibroblasts causes activation of latent TGFβ via integrins; this activation is blocked by the actin/myosin destabilizing agent blebbistatin which blocks ECM contraction by fibroblasts [24], [29], [30].
In order to make further claims about the functional relevance of the motor system for processing of emotion word stimuli, it is necessary both to further investigate the temporal dynamics of this activation via a method with fine-grained temporal resolution and to study processing of these words in patients with functional impairments to the motor systems.
Moreover, immunoblotting analysis demonstrated that this activation was via an Akt-dependent pathway.
If activation of host erythrocyte MEK1 is required for parasite survival, and if this activation occurs via PAK-mediated phosphorylation of MEK1 Ser-297, then we would predict PAK inhibition to have similar parasiticidal effects as the MEK inhibitors.
This activation via glucorticoids signaling pathways was fully prevented by cyclotraxin-B, contrary to a functional anti-TrkB antibody capable of inhibiting BDNF-dependent TrkB activity only.
This activation, via fibroblast growth factor receptor 4, leads to the repression of cholangiocyte sterol-27-hydroxylase (CYP27), which is the rate-limiting enzyme in the acidic pathway of bile acid synthesis.
In the case of a known transcriptional activation of any gene by the stimuli TNFα or TGFβ1 via a specific TF, this activation was represented in the network using the term GENE.out = STIMULUS AND TF.
As shown in Figure 4, the absence of ABCA1 does not affect PS exposure via this apoptotic activation pathway, either.
This activation occurs via alkylation of key cysteine residues on the KEAP1 protein, which blocks KEAP1-dependent proteolysis of Nrf2.
In transfected model systems, G-protein-coupled receptors that couple to pertussis toxin-insensitive G proteins of the Gq/11 family mediate this activation predominantly via a PKC-dependent mechanism.
This activation occurs via a Ras/Rac1/Pak1/MKK4 pathway.
