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For these authors, smoking during pregnancy induces reduction in foetal cord serum leptin concentration through depletion of foetal energy stores directly via substances present in tobacco smoke or indirectly by compromising nutrient supply consequent to induced placental changes.
A possible mechanism for the link between infection and pre-term delivery is bacterial stimulation of the biosynthesis of prostaglandins, either directly via phospholipase A2 and C [ 148], or indirectly via substances such as interleukin-1, tumour necrosis factor and platelet activating factor, all of which have been identified in infected amniotic fluid [ 149].
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3) This work provides evidence that Bk can act directly on motor output, rather than indirectly via Substance P release.
Furthermore, as requested by the reviewer we soften throughout the manuscript our conclusions on a direct postsynaptic effect of Bk. 3) This work provides evidence that Bk can act directly on motor output, rather than indirectly via Substance P release.
Since application of noradrenaline at high concentrations (10-6 M) via β2-adrenoceptors is anti-inflammatory by strongly inhibiting TNF, the loss of sympathetic nerve fibers in inflamed tissue of RA patients leads to a proinflammatory situation (TNF is stimulated via substance P receptors and α-adrenoceptors at low noradrenaline concentrations of 10-8 M).
The corrosion-relevant microbes like to attach to solids via exopolymeric substances (EPS), which give the main component of the slime and form biofilms at the solid liquid interface.
In the footwear industry, the most commonly used chemical treatment is via halogenated substances.
For some, the only way to keep an illusion of youth is to cheat the body into thinking it can work via illegal substances that can only harm it in the long run.
Substance use, via the Substances and Choices Scale [ 56], which is a one-page self-report questionnaire designed for young people aged 13-18 years and takes about 5 minutes to complete.
Platelets not only play a role in hemostasis but also play a role in inflammation via releasing substances with physiologic potential and by interacting with leukocytes and vascular endothelial cells involved in modulation of the inflammatory reaction [ 39].
Following conditioning film formation, microbial biofilms develop by adhesion of individual cells via exopolymeric substances to a "conditioned" particle surface, followed by growth of microcolonies and further colonization by one or more microbial species.
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